A friend of mine, Eric Engstrom, died of liver failure after taking (too much) Tylenol. Tylenol use over time can sneak up on you in the form of cumulative liver damage.
No, I'm not a doctor and this isn't medical advice.
Personally, a works-most-of-the-time treatment for headaches is going out for a walk. I don't know why it works, but it does.