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likely no_std, and running via Win32s. Rust doesn't have support for segmented memory, so native 16-bit would be much harder

I believe there is AVR support for Rust, which is 16-bit with separate code and data pointer types?

sorry, i was referring specifically to the x86 segmented memory model: https://en.wikipedia.org/wiki/X86_memory_segmentation (basically, near and far pointers)