Lately I've been using umu-launcher [1] which is a wrapper and compatibility tool for the proton used by steam and I'm quite satisfied about it. It's shipped with configurations for 3000+ games, might be worth a try if you're having trouble with the configs.

Take it with a grain of salt, I don't have much experience in running windows application on Linux, I just had some problems with wine and I discovered umu to be pretty straightforward and easy to use.

[1] https://github.com/Open-Wine-Components/umu-launcher

Same here. I used to have great success with PlayOnLinux, then it seems worked on it ceased 3-4 years ago? It was very duplicative, making a fresh Wine environment for each application, but for that cost it seemed to be less prone to issues than other approaches in the 2010-2020 era.

This doesn't seem to be using Wine though, as it requires Docker it's likely something lower level than a compatibility layer that translates syscalls.