Python is surprisingly heavy-duty. But my kingdom for a seamlessly distributed or parallelized version of NumPy/SciPy! How nice would it be to just enter "C = A * B", with A living as a sparse CSC across many nodes?
EDIT: or did you mean Disco offers distributed sparse CSC operations?
For example, instead of computing an exact SVD, you will use something like Hebbian algorithm to compute the SVD in a streaming manner (that's what Mahaout implements for example).