Initially I built only a desktop client, because I didn't like IndexedDB. After the app got into HN, someone recommended to check for OPFS (Origin Private File System).
Now we have a full offline-first app in web using SQLite on top of OPFS. We didn't test it with large scale yet, but so far looks very promising. The good thing is that we use Kysely as an abstraction for performing queries in SQLite which helps us share most of the code across both platforms (electron + web) with some minor abstractions.
You can check the implementation in Github: https://github.com/colanode/colanode