I wonder about something like https://secureblue.dev/ though. I'm not comfortable with Fedora and last I heard it wasn't out of Beta or whatever yet. But it uses containers rather than VMs. I'm not a targeted person so I may be happy to have "good enough" security for some performance back.
some corrections:
> last I heard it wasn't out of Beta or whatever yet
It is
> But it uses containers rather than VMs
It doesn't use plain containers for app isolation. We ship the OS itself as a bootable container (https://github.com/bootc-dev/bootc). That doesn't mean we use or recommend using containers for application isolation. Container support is actually disabled by default via our selinux policy restricting userns usage (this can be toggled though, of course). Containers on their own don't provide sandboxing. The syscall filtering for them is extremely weak. Flatpak (which sandboxes via bubblewrap: https://github.com/containers/bubblewrap) can be configured to be reasonably good, but we still encourage the use of VMs if needed. We provide one-click tooling for easily installing virt-manager (https://en.wikipedia.org/wiki/Virt-manager) if desired.
In short though, secureblue and Qubes aren't really analogous. We have different goals and target use cases. There is even an open issue on Qubes to add a template to use secureblue as a guest: https://github.com/QubesOS/qubes-issues/issues/9755
Hearing not to rely on it from the developer of secureblue is pretty strong case. Thanks.