> “In the back of my mind, I kept thinking that if we could produce this type of light immune activation in other people, we could protect them from just about any virus,” Bogunovic says.
This sounds terrifying. There's a reason our bodies do not regulate like this.
>Bogunovic’s therapy is designed to mimic what happens in people with ISG15 deficiency, but only for a short time.
Given the choice between 2 weeks of a moderate COVID infection (fever but no hospitalization), and 2 weeks of this therapy, I would guess that the moderate COVID infection gets you at least 10x the inflammation.
But the article didn't talk about imposing constant low-grade inflammation. In fact, they specifically said they were talking about 3-4 days.
I can't remember which series it was, though.