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I am not a medical expert, but from what I read the last time I saw this being discussed, ISG15 deficiency also causes something called "infernopathy" that leads to inflammation across the entire body. I don't believe it's related to viral activity at all.

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From TFA: "We only generate a small amount of these ten proteins, for a very short time, and that leads to much less inflammation than what we see in ISG15-deficient individuals,” Bogunovic says. “But that inflammation is enough to prevent antiviral diseases."

It seems that the goal is to learn to trigger the benefits, without triggering the bad parts. Which, should probably have been obvious to you without even bothering to read the article.

The weird thing about this quote: is the inflammation enough to prevent viral diseases, or antiviral diseases?

To the extent the disease is due to factors hurting the virus, I guess it's viable as a perspective, but I'd be surprised if it's deliberate in this case.

Probably just a mistake. I don't believe there is such a thing as an "antiviral disease".

A virivore infection could count I guess? But probably not what they meant.

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