We have been doing this for decades, it's how refrigerants work.
The part that is new is not having an air-interface in the middle of the cycle.
Water isn't the only material being looked at, mostly because high pressure PtC (Push to Connect) fittings, and monitoring/sensor hardware has evolved. If a coolant is more expensive but leaks don't destroy equipment, and can be quickly isolated then it becomes a cost/accounting question.