If Youtube stops working with uBlock Origin, I'll just download the videos wholesale and watch them that way instead, and I doubt there's a realistic way to completely block that, and there will be/already is a large community of people who are willing to make that experience as smooth as it can be, if need be. I don't see an end that works out significantly worse for adblockers in the long run, so everything in the short term is just busywork.