I chose Play! (1.x) because it is by far the most productive development environment I have ever used (especially for boring business admin pages). (Out of Django, JSP, Lift, GSE/GXP, Jetty, etc).
http://code.google.com/p/gorilla/
https://github.com/bmizerany/pat
And just say no to ORM.
Disclaimer: I contributed to the original Gorilla design, but all the credit should go to moraes (and everyone else who was contributed to the project).
For my own part, a lot of my work has some connection to a scaling problem of some kind. A mandatory/single-database-type ORM is totally out of the question and largely why I had to abandon Django for Flask in my Python work. I might at some point migrate to Pyramid for Python, but I haven't evaluated the state of their persistence story. I was mostly wooed by their testing strategy (it's drop dead sexy).