I know the kindle uses e-ink which i've read about , but I wanted to get the opinion of others that may experience eye strain when reading from devices, and if they've had success with any of these readers!
Then one day I was on a flight and flipping through SkyMall and saw an ad for "computer glasses" that got rid of eye strain. i was like "yeah, right". But I was desperate, so I bought a pair, and I gotta say, it's been one of the best purchases I've ever made. I no longer have eyestrain, can read for hours online.
Here is the brand of glasses I got: http://www.gunnars.com/
However, despite the Kindle engineers' efforts, the text still appears to float a bit above the screen rather than appearing to be firmly printed on the device itself. So, you will experience some slight annoyance there.
Incidentally, I've heard lots of good reports about the use of f.lux to minimize eye strain on screens, and experienced it myself. You might want to try that for when you need to use screens.