sqlite is probably our best example. The project touts use within Airbus A350 and DO-178B certification.
Is there no performance requirement on these? Surely there must be. You can't wait forever for a response; safety critical systems are only safe if they work in time.
Safety critical is of course also performance critical to an even greater extent than games. You can usually get away with a dropped frame but you can't miss, say, valve timings.