Not without rebuilding the whole document and editing the source code. A lot of packages only have a few sizes they support on top of that.
The dimensions of all the documents I've written over the years depend on the document class I use, and as our company keeps changing document layout standards every few years, the document class changes as well.. but the only source editing necessary is to replace the very first line in the document, i.e. changing the document class. And the whole document changes. Sometimes completely, much more than just sizes.
But, yes, PDFs are intrinsically non-resizable.