For melatonin, tryptophan plus niacin would maximize the serotonin pathway (note this is dangerous when used with SSRIs).
How many of these are easily available? I had no idea that royal jelly is sold as a supplement.
It is also likely the most easy to study, as we have 60-70 years of usage that is not correlated with prevalence of other diseases that might skew life expectancy (like metformin etc.), and quite high-quality medical records by virtue of it being vended on a prescription basis.
Despite this, there is not really any clear evidence that it increases life expectancy.
Hormonal contraceptives typically do not contain estradiol, but ethinylestradiol and/or progestins.
I know this because I recently had to source exogenous Estradiol for my wife after making this same mistaken assumption and being surprised at bloodwork and lack of improvement
Given that actual honey on the shelf is often mere sugar water, and people buy chakra-alignment crystals online, what about the idea surprises you?