Author here if you have questions about some obscure circuitry in the 386.
Like anything to do with metastability this is a statistical thing - it can do this, but it's highly unlikely.
I worked on a chip in the mid 90s where we were very careful about our clock crossings, dropped in special high-gain anti-metastability flops, designed logic to reduce synchronised signal frequencies etc etc all the good stuff - we calculated that we'd see a failure (and mostly that would be a pixel burble on the screen) every year or so - at the time Win95 couldn't stay up a week so management decided to ship it
These days, I leave chip design to chip designers and barely do silly things like create seven (7) total 4 pin to 3 pin Arduino PWM fan controllers with MOSFETs, MOSFET protection and noise reduction circuitry. See, I have to keep the fans fed with over 4 volts so the tach signal continues and the storage array's BMC doesn't freak out. (The fans characteristics I needed aren't/weren't available in 4 pin PWM.) I try not shock myself like ElectroBOOM or release too much magic smoke from gear or vintage gear that might not be replaceable.
This article, from a company that designs ESD circuits, describes various modern techniques: https://monthly-pulse.com/2022/03/29/introduction-esd-protec...