There are weapons that can permanently paralyze an entire city. Not paralyze infrastructure or traffic... but permanent incurable paralysis of all the people in any area exposed to the weapon. That is still a 20th century technology.
Mind sharing some links? Curious what you are talking about.
That's a hell of a claim, and unless you're talking about some kind of chemical spray or seeding some weaponized microbe across the city, you could at least post a link or name that explains what it is.
Of course there are. I learned about that reading the works of Milo Rambaldi.