If a plane can land anywhere to refuel and takes off again in 10 minutes, the other side needs a fast kill chain to catch the plane.

But if they land on big well known bases, it's much simpler.

Another comment here about slow drone speeds and nest drones:

https://news.ycombinator.com/item?id=44918955

And sometimes the other side can destroy all big airbases in a small country.