Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier
The issue with regaining weight after coming off these drugs is that people don't change their habits, and once they are off, they no longer have the limited appetite, and return to eating like they did before, which just results in the problem reoccurring. Uncouplers won't change this.
If people want to sustain their weight loss, they either need to change their lifestyle and eating habits, or they need to stay on the drugs, and potentially even both.