Regarding the GDP needed once you have a working "mine from the moon and send to orbit" economy it doesn't seem to be too bad. The assumption would be that a lot of technology is already developed for other projects. Launching it all from earth obviously wouldn't be possible even with vastly cheaper launch. That's why they put the build into the moon-earth L1 lagrange point to be easily reachable from the moon.
For propulsion and reactors, but there are multiple projects today working on all of this. Building a life support system for 400 years is still an unsolved problem however.