And I really dont see how Semantic.gs isn't responsive? Set its grid representation to percentages, write a few media queries, and its as responsive as any other grid system out there. The inherent behavior of the CSS box model + Percentage based semantic.gs + media queries is as responsive as I think you can get.... its all I've ever needed to do ANY responsive design I can imagine. I've never felt limited by Semantic.gs in terms of responsive design.
I really dont see how you could make that any easier? Are your mixins generating media queries? Is it really that hard to calculate a golden ratio and use it with Semantic.gs?
Edit: http://semantic.gs/examples/responsive/responsive.html they even have a Responsive example on the front page of their website, so I really dont understand why you think Semantic.gs isnt responsive?
> i.e. it doesn't come with a straightforward way to change the grid for specific breakpoints.
isn't that what media queries are for?