>My opinion is to wait long enough to validate there are no long term harms,
What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.
What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.
my estimate would bigger than others and I would put it at 30-50years.
I take smoking as a cautionary tale, in the beginning it was pushed as not just a recreational thing but a healthy activity that bring benefits with papers published to sing praises about it. my parents were even nudged by their teachers/doctors/etc when they were young to try smoking.
now we all know that smoking is beyond bad and all that early "research" was just people paid off by big companies to promote it.
We performed the surgical options like stomach reduction before this which come with serious danger for comparison
While i agree the gist of what you are saying, also important to mention that humans started cultivating tobaco when mamoths still roamed the Earth. There was indeed a concentrated pro-smoking publicity campaign by tobaco manufacturers in the 1930s, but it was hardly “in the beginning” of our tobaco use.
Links to these papers? I’ve always been curious because I’ve seen this claim many times, especially on HN but no one has ever managed to actually provide a source on one.
There is no modern-style research touting the benefits of smoking qua smoking. I will grant you there might've been some crank self-publishing something, like some of Aristotle's writings.
But you won't find what we'd consider today an acceptable, reputable form of research saying this.
A quick Wikipedia search shows Exenatide was FDA approved in 2005 for diabetes.
Exenatide had been in use since about 2005, and by 2019 had more than a million people on it. Some of those patients have literally been on it for 20 years. It does have a worse side-effect profile than Ozempic (or the more modern GLP-1's like zepbound), but even then the benefits outweigh the risk for those diabetics.
Today it is hard to argue the benefits of modern GLP-1s don't outweigh their risks. They've been extensively tested, the class of drug has been around for decades, and they are used by many millions of people.
I personally lost 120 pounds on Zepbound in a little less than a year. It's been life changing, and anyone who thinks I might be less healthy now is very clearly wrong. Literally every aspect of my life has been greatly improved.