Bacillus thuringiensis is the most used pesticide in existence and has been for nearly a century. We’ve sprayed it everywhere in huge quantities, including on pretty much anything labeled “organic.”
The end product is produced in large submersion fermentation tanks where the bacteria is first grown, then then forced to sporulate and allowed to ferment which produces the Cry/Cyt toxin crystals within the spores. Going through these phases requires precise control over nutrients, pH, agitation, and electron acceptors. Even activating the spores to create the inoculum and begin the reproductive cycle is nontrivial because of how sterile everything needs to be.
I did skim read a few papers on the subject and honestly I'm wondering how this stuff even grows naturally, everything has to be so specific it just doesn't seem possible at all.