New drug could halt Alzheimer's

I have a dog in this fight as the neurostimulation technology we're developing at https://affectablesleep.com has been shown to improve amyloid response AND memory in healthy older adults[1], as well as increase sleep in people with mild to moderate Alzheimer's[2].

There are significant studies showing safety in slow-wave enhancement, and I am yet to see a single study that shows any negative impacts. The stimulation works (it is thought) by triggering a protective mechanism in the brain which increases the synchronous firing of neurons known as slow-waves which improves the glypmphatic systems power to flush out metabolic waste (amyloid, tau, etc).

Pharmaceuticals have complex interactions which, thus far, neurostimulation does not appear to have. As the article points out "the risk of brain swelling and brain bleeds means they need intense monitoring"

There is also https://www.cognitotx.com/, which uses an open-loop auditory and visual stimulation which seems to have similar response in the brain. However, from what I'm told the stimulation is quite exhausting.

https://doi.org/10.1093/ageing/afad228 https://doi.org/10.1016/j.jagp.2024.07.002