I agree, most medications will create/change tolerance to more of the same. In some respect that's the purpose of taking some medications in the first place, but it can lead to poor long term outcomes. Take enough melatonin exogenously and your endogenous production stops completely.

“I took five people, and we locked ourselves in a building for three weeks, and we took 400 micrograms of LSD every four hours. That is 2400 micrograms of LSD a day.… We finally were just drinking out of the bottle.… We were very high.”

From Be Here Now - Ram Dass/Richard Alpert

Interestingly he was the guy involved in giving psilocybin to priests back at Harvard in the 1960's.

Recent source: https://tripsitter.substack.com/p/ram-dass

On the other hand, one single dose of a psychiatric medication can ruin peoples lives. They get brain shocks, sexual dysfunction or anhedonia for life. One dose of marijuana can effect similar outcomes.

I know immunosuppresants are whole separate part of medicine, but its a playing with fire risk/reward where its too early to establish reasonable probabilities. But at least we can begin the cause-effect discovery process.