Personally, I've had my Caps Lock key bound to Escape for quite a few years now. It has been lovely and fits perfectly with my keyboard-driven workflow. Pairs great with Colemak-DH, which is my layout of choice.

I haven't found myself ever missing the Caps Lock key's original functionality, and my blank laptop keycaps mean I can have it bound without mental annoyance.

Some good discussion: https://www.lesswrong.com/posts/hPLvZsNZGsQSLfMee/remap-your...