Hi rsyring, I made this comment out of experience.

As python projects grow and grow, you need to do lots of support work for testing and even syntactic correctness. This is automatic in compiled languages where a class of issues is caught early as compile errors, not runtime errors.

Personally I prefer to move more errors to compile time as much as possible. Dynamic languages are really powerful in what you can do at runtime, but that runtime flexibility trades off with compile time verification.

Of course, every project can be written in any language, with enough effort. The existence of large and successful python projects says nothing about the developer experience, developer efficiency, or fragility of the code.