AFAICT this does not quite produce true binaries, but rather interprets C++ via Cling, is that right? And the docs only offer that C++-like speeds are achieved for PyPy. If there are any performance benchmarks for CPython3, I can't see find them. Thats the real question - few people combine Python and C++ just for the fun of it.
EDIT some benchmarks are available in this paper, linked from TFA: https://wlav.web.cern.ch/wlav/Cppyy_LavrijsenDutta_PyHPC16.p... But they don't really answer my question. The benchmarks seem to mostly look at the overhead of wrapping C++, rather than comparing to a Python implementation. There is some I/O involved in some of them, which is maybe not so interesting, and some of the benchmarks don't even have a pure CPython implementation. Where they do, speed is very close. But then the paper is from 2018, a lot may have changed.