I recall being on a road trip and was at the foothills of the Sierra Nevada mountains; was getting ready to camp at a random camp site and noticed a sign warning or squirrels that carry bubonic plague via fleas…
Scary..
Do you mean 'naturally' by their own selection, or some external means?
Lime disease has a similar relationship with predators that eat mice, so let's also keep an eye out for the owls and snakes.
Reduces spread and increases evolutionary pressure to increase resistance and possibly even become immune.
Selection would favor pathogens that instead specialize for hosts that are hard to get rid of. Mice, cockroaches, prairie dogs...
So you’re going on a walk one day, they seem friendly, people like handling cute animals… bada big bada boom