The 2024 Ukraine defense funding bill passed despite having < 50% support in the majority party in the House, and it was not part of a reconciliation.
Affordable Care Act (Obamacare) was the most sweeping legislation ever passed via reconciliation.
Obamacare was passed via regular order (60 Senate votes), not reconciliation. There was a follow-up package to tweak it that passed via reconciliation in 2010, but the original bill was regular order. It's the only (very brief) window where one party has held 60 Senate seats since 1977.
Whoops! I remembered the reconciliation but not the initial vote.