Similarly to the sibling I also use both. I let mise manage my uv version (and other tools) and let uv handle Python + PyPI Packages for me. Works great!

There's also some additional integration which I haven't tried yet: https://mise.jdx.dev/mise-cookbook/python.html#mise-uv

Think of uv more as like npm or other thing like that. The new Python pyproject.toml is similar package.json. It defines the project description, list of dependencies, and other hooks. Uv is a package/project tool using pyproject.toml. It is easy to manage dependencies, build and publish to PyPi, add hooks to run tests, linters, or whatever, again much like package.json. It also manages the virtualenv automatically, though you can manage it yourself.

Thanks for mentioning mise. I'm more interested in it for the task running feature. I couldn't figure out how to have shell scripts in Justfile, so I gave up on it.

I use both! uv installed globally with mise, and uv tools can then be managed via “miss use -g pipx:foo”.