They might be fanatical, but to the point of desiring the destruction of themselves, their loved ones, their country, their culture, their literature, their history.. just to inflict genocide on others? This is a dehumanising thought.
Besides, the fanatical leader of that country has said in clear terms that they consider nuclear weapons forbidden by their religion. They have also said in clear terms that oppose the "Israeli regime" and the existence of Israel as a political entity- that's what they mean by "destruction of Israel", not nuking it.