High levels of antihistamine drugs can reduce fitness gains

This is really interesting, as I came to a similar conclusion recently. I was taking famotidine (h2 blocker) and fexofenadine (h1 blocker) and noticed my daily running routine became significantly more difficult. Within a few days of stopping both, it became easier again.

Having had to figure out a physiological puzzle involving histamine as an alertness-promoting neurotransmitter, and getting to see adult-onset Type 1 diabetes up close where histamine is intimately related to everything as a core part of glucose metabolism – both these aspects of histamine are well known but surprisingly underdiscussed! — I have come to see histamine as sort of a “tissue opener” signal. And with all as the vantage point, the perspective afforded even just by the headline makes immediate and intuitive sense.

Important note, but still very interesting research!

> Halliwill emphasized that the new studies and other related research use very high doses of antihistamines, much higher than what a person would consume to combat allergies. More evidence is needed to know whether a low-dose daily allergy medication could interfere with fitness.

Ma gains

I have awful hay fever, so take them religiously.