Nihilism, not even once. It's a hell of a drug that'll wipe out all meaning and purpose from life leaving you cold, detached and suicidal.

Meaning is emergent and constructed from our experience of being physical beings in the real world. Just because that's mediated through our thoughts and senses doesn't suddenly strip it of existence or relevance.

Even reflecting on the nature of consciousness is contingent on so many other more fundamental lived experiences and mental abstractions. It's turtles all the way down and meaning is found/constructed in every layer.