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The amount that has to be destroyed is miniscule.

my point is that powders don't mix evenly. part of a baggie testing negative for fentanyl doesn't mean the remainder is clean.

Then thoroughly mix the whole amount before taking a sample.

Given that a lethal dose of fentanyl is about two milligrams (similar to 5-7 grains of table salt in volume), that still feels pretty risky.