Pipelined State Machine Corruption
flak.tedunangst.com
flak.tedunangst.com
Probably the main reason it is recommended against.
Of course this might be a dumb example in this case because the process mailbox will do the right thing and be a queue if you just blockingly make the dns request in your handler process. (It also might not be, I don't know enough about the smtp state machine to say.)
(I don't why this is not mentioned in RFC 2920.)
Sendmail, just say no.
Which is the incorrectly addressed RCPT TO and why is it so?