I have ADHD, amfetamines help me relax, caffeine causes me to fall a sleep, some anti-allergy medication can cause me to stay awake for 2 days straight.
I read that in some countries doctors can prescribe mild sleeping pills for babies to help them stay calm during long flights. They always advice to test it before going on the flight, because some babies can actually become hyperactive from that medication. If that happens, there's a good chance the baby has ADHD.
- diphenhydramine aka Benedryl is an antihistamine with a common side effect of sleepiness
- doxylamine aka Unisom is also an antihistamine but these days people only really use it as a sleep aid or for nausea
- psuedoephedrine aka Sudafed is a decongestant. Not sold over-the-counter because it can be used to make meth. It's a stimulant and appetite supressant
Finally, there's "Sudafed PE" aka phenylephrine, which is also sold as a decongestant but it (literally) doesn't work
The best I can describe it is that I felt calmer in my mind, but overstimulated in my physical nervous system.