As far as I’ve understood, pure nicotine is not significantly addictive in most people.
What is very addictive, though, is the synergistic effect nicotine has with MAO inhibitors, such as those found in tobacco smoke or vape/gum/pouch flavorings.
What is very addictive, though, is the synergistic effect nicotine has with MAO inhibitors, such as those found in tobacco smoke or vape/gum/pouch flavorings.
Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations https://www.frontiersin.org/journals/psychiatry/articles/10....
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products https://www.sciencedirect.com/science/article/pii/S221475001...
There is of course variance depending on the exact flavorants used. For example, menthol and mint flavors don’t inhibit MAO, their activity is towards kappa-opioid agonism (induction of dysphoria).