There are only like 3 major ones. You can block those IPs too.
So the point of this is to prevent Comcast from seeing your DNS queries. And then it works fine to trust the network to say "no, really, use this one and not the default DoH one" as long as that setting is one that Comcast would get in trouble for misusing. Notice that they don't return bad results for use-application-dns.net as it is.