If the goal is viable commercial operation, Helion has vast benefits over the other approaches when it comes to the economics of turning the fusion energy into electricity.
All approaches have huge hurdles to overcome. Helion may have bigger challenges on the Q side, but all-in-all I think the probabilities of being viable ends up similar.
All other fusion power plants are thermal power plants. I suspect all thermal power plants will end up being economically unviable in the world of renewables, for various reasons. They’re just too bulky and slow, and require special consideration wrt cooling. It’s one of the reasons why gas power is king these days.
If we think really far ahead, the scaling of thermal power plants is limited by the heat they put out. It ends up contributing to global warming just from the thermal forcing they apply to the environment. The effect of the ones we have today are already surprisingly significant. Helion is a path to being able to produce a huge amount of energy with fairly limited impact on the environment (eventually limited by the thermal energy they dump, but perhaps they can use thermal radiation panels that dump the waste heat energy directly to space)