I haven’t taken it myself, but I’ve heard of methylene blue being helpful, especially post TBIs or head injuries.

Wrt ibuprofen, I find it can (at times) massively clear out my brain fog. I suspect it’s primarily due to its anti inflammatory effects. The worse my baseline is, the more noticeable its benefits (upto a point, and apparently dose dependent). I often feel inflammation due to less sleep and due to another chronic heath condition, ibuprofen is like wiping a dirty glass or window clean.

I should probably add that I likely have more inflammation than the average person by a significant amount unfortunately, so your mileage may vary, but when I mentioned it to my GP he wasn’t surprised at all at its effects.

Methylene blue is said to allegedly have helped some people with brainfog - especially after covid. But the research is really scarce. Ibuprofen and creatine may also have some positive nootropic effects with recently mounting evidence, but at least they were already very well studied before because of their actual uses. So if anybody wants to try this stuff, I'd stick with those.

I forgot to mention and wanted to add, I would recommend you to go to forums with people far more knowledgeable than me.

Reddit’s r/nootropics is one, I seem to remember blue light forum and longecity also have lots of info about more “cutting edge” experimentation.

As always, be cautious, and oftentimes common and well tolerated things (for example theanine) can be much better than some research peptides.