Genndy Tartakovsky is a truly unique creator. Samurai Jack was so good, that I had to watch how it ends years later since watching the show on cartoon network
It also produced some well-known cartoonists who went on to have very successful careers: most notably Seth MacFarlane, creator of Family Guy.
So what about Pantheon? It doesn’t seem relevant to this discussion apart from it also being animated.
I hate simulation theory, and even with that bias, that show had so many cool concepts.