A system with say 192GB VRAM and rest standard memory (DGX station, 2xRTX Pro 6000, 4xB60 Dual, etc.) could still in theory run Deepseek @4bit quite quickly because of the power law type usage of the experts.
If you aren't prompting Deepseek in Chinese, a lot of the experts don't activate.
This would be an easier job for pruning, but still I think enthusiast systems are going to trend in a way the next couple years that makes these types of software optimizations useful on a much larger scale.
There's a user on Reddit with a 16x 3090 system (PCIE 3.0 x4 interconnect which doesn't seem to be using full bandwidth during tensor parallelism) that gets 7 token/s in llama.cpp. A single 3090 has enough VRAM bandwidth to scan over its 24GB of memory 39 times per second, so there's something else going on limiting performance.