C/C++ is a PITA and I'm not a C/C++ developer, but I do find that I'm able to get around the issue 90% of the time using steam-run (although that feels kludgy as hell and I really wish there were a better option for getting linked libraries working normally). I think the real answer is to get good enough with nix to build a flake quickly for the project you're working with, but that seems like a lot to learn. Maybe easier if you're more familiar with C/C++ dependencies and build tools than me though.

Musnix looks really interesting. My whole audio setup looks like this in my nixconfig:

   hardware.pulseaudio.enable = false;
   services.pipewire = {
     enable = true;
     alsa.enable = true;
     alsa.support32Bit = true;
     pulse.enable = true;
     jack.enable = true;
   };

   hardware.bluetooth.enable = true;
   hardware.bluetooth.powerOnBoot = true;
   services.blueman.enable = true;

This works great for my workflow of using headphones + BT 100% of the time, but weirdly it almost never works for the built-in speakers on my framework. I might try musnix if that ever bothers me, but it's actually kind of a feature for me since my laptop can never just start blaring whatever I was watching / listening to into public