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Is it natural, or have we just adapted to it? Maybe if we had always had 10-day weeks, we'd get sick if we switched to 7.

This cannot be right.

I've known multiple people in my life whose working shifts do not correspond to the seven-day week.

I know of no illness from which they suffer.

People get sick when it's changed. People get sick when it's unchanged.

No other primate cares a whit. No other animal cares a whit.

Citations would be very useful here, otherwise it sounds like another random thing from minds unknown.

What do the symptoms look like?

The symptoms could be connected to emptyer wallets, because on workdays people earn, on weekends people spend. It would take time and shifting of minds to adapt countrys economics to, for example, three day weekend.