Bach's fugues are amazing, they sound great on harpsichords and organs, whereas some piano music sounds very wrong when it is payed without all the volume modulation, the fugues are carried by the interactions between the melodies, the counterpoint.
https://www.youtube.com/watch?v=ddbxFi3-UO4
to the a cappella version by the Swingle Singers:
https://www.youtube.com/watch?v=uhU7euFPWwo
Some music is very much tied to a particular instrument, but Bach is more or less universal.
The two pauses in contrapunctus 1 are, in my opinion the two best pieces of silence in the whole musical canon. I always think of the chords that come after theme as 'from his mother's womb untimely ripped'. They can make me weep when I'm in the right mood. (sorry for the over-sharing...)