This article felt like a strong argument against Nix rather than in favor of it. The complexity it brings is just not worth the gains for the majority of people that I know. No, most people won't be happy that Nix breaks dynamic linking.

Docker with a Debian Stable base will solve the problems listed for most users, with 1% of the time investment. The author used Nix for 8 years, and I'm not surprised it looks a bit simpler to them now.