Some remote companies such as Atlassian, Affirm, Dropbox have different pay zones to offset the cost of living in various places.
For example, in Atlassian https://www.atlassian.com/company/careers/resources/intervie..., the 3 pay zones are - Zone A: SF - Zone B: Boston, LA, NYC, Sacramento, San Diego, Seattle, Washington D.C. - Zone C: all others Zone B is 90% of Zone A's pay and Zone C is ~82% of Zone A's pay.
Agree that company willing to accept remote work has a broader talent supply and can be an advantage in hiring talents not in the big tech cities. I am not sure if it necessarily lead to lower labor cost due to competitions with other remote companies also hiring in those regions. Competitions would help keep the labor cost up.