From what I can tell, the only significant difference between C and Odin mentioned in the post is that Odin zero-initializes everything whereas C doesn't. This is a fundamental limitation of C but you can alleviate the pain a bit by writing better primitives for yourself. I.e., you write your own allocators and other fundamental APIs and make them zero-initialize everything.
So one of the big issues with C is really just that the standard library is terrible (or, rather, terribly dated) and that there is no drop-in replacement (like in Odin or Rust where the standard library seems well-designed). I think if someone came along and wrote a new C library that incorporates these design trends for low-level languages, a lot of people would be pretty happy.
[1]: https://www.rfleury.com/p/untangling-lifetimes-the-arena-all...