MySpace had that huge advantage of many sticky users, but they stopped improving it, and a competitor (Facebook) made an improved experience.
Twitter is safe for as long as there isn't a sufficiently better competitor - "better" being in terms of the benefit to users, not any engineering quality in itself.
Facebook rolled through phase 1 by being exclusive, then phase 2 by first saturating college students, then they exploded beyond what any social network had ever known by offering a clean, curated and controllable experience that steadily roped in older people by being the place to stay in touch with younger friends and family.
I always laugh when people trot out MySpace as a cautionary tale for Facebook, because it's irrelevant. MySpace was the 500lb gorilla in 2004, but Facebook is the only 5000lb gorilla that ever existed. Whatever bring them down won't be for the same reasons that MySpace failed.
MySpace definitely hit the growth curve early since it was wide open, and Facebook wasn't open to non-college-students until when, mid-2006?